---
title: "Scientific Publications"
canonical_url: "https://www.newpathology.de/publications/"
language: "en"
site: "New Pathology"
---
# Scientific Publications

Selected peer-reviewed publications authored or co-authored by Dr. Lukas Heukamp in molecular pathology, precision oncology, oncology biomarkers, and genomic diagnostics.

This list is generated from PubMed and refreshed automatically during site builds.

These publications reflect work in molecular pathology, translational oncology, biomarker research, genomic diagnostics, liquid biopsy, and related areas of precision oncology.

## Selected publications

- [Liquid biopsy-based detection of acquired MET resistance enables sequential targeted therapy in MET fusion-positive NSCLC.](https://pubmed.ncbi.nlm.nih.gov/42015375/) — Rosnev S, Klein K, Heukamp L, Lenk J, Joosten M, Möbs M, Grob T, Benary M, Vecchione L, Ott CE, Modest DP, Knödler M, Keller U, Frost N, Keilholz U, Kiewe P, Rieke DT — The oncologist. 2026 (PMID: 42015375)
- [Characterization of synaptopodin in striated and smooth muscles: isoform spectrum, expression patterns, localization and protein interactions.](https://pubmed.ncbi.nlm.nih.gov/41941933/) — Lohanadan K, Assent M, Linnemann A, Qu C, Schänzer A, Heukamp L, Milting H, Kirfel G, Miner JH, Fürst DO, van der Ven PFM — Experimental cell research. 2026 (PMID: 41941933)
- [Editorial Expression of Concern: Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.](https://pubmed.ncbi.nlm.nih.gov/41266687/) — Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R, Ansén S, Perner S, Brockmann M, Bos M, Wolf J, Gardizi M, Wright GM, Solomon B, Russell PA, Rogers TM, Suehara Y, Red-Brewer M, Tieu R, de Stanchina E, Wang Q, Zhao Z, Johnson DH, Horn L, Wong KK, Thomas RK, Ladanyi M, Pao W — Nature medicine. 2025 (PMID: 41266687)
- [Detection of ESR1 Mutations in Tissue and Liquid Biopsy with Novel Next-Generation Sequencing and Digital Droplet PCR Assays: Insights from Multi-Center Real Life Data of Almost 6000 Patients.](https://pubmed.ncbi.nlm.nih.gov/40282442/) — Borkar S, Markus F, Oetting A, Schmidt S, Vössing C, Horst D, Möbs M, Braicu EI, Griesinger F, Horling K, Tiemann K, Heukamp LC, Willing EM, Vollbrecht C — Cancers. 2025 (PMID: 40282442)
- [Intergroup-statement: statement of the german ovarian cancer commission, the North-Eastern German Society of gynecological Oncology (NOGGO), AGO Austria and AGO Swiss regarding the use of homologous repair deficiency (HRD) assays in advanced ovarian cancer.](https://pubmed.ncbi.nlm.nih.gov/40069521/) — Chinczewski L, Harter P, Heukamp L, Mayr D, Grimm C, Heinzelmann-Schwarz V, Wimberger P, Mahner S, Braicu IE, Schmitt W, Denkert C, Sehouli J — Archives of gynecology and obstetrics. 2025 (PMID: 40069521)
- [Targeting KDM1A in Neuroblastoma with NCL-1 Induces a Less Aggressive Phenotype and Suppresses Angiogenesis.](https://pubmed.ncbi.nlm.nih.gov/39458030/) — Sprüssel A, Suzuki T, Miyata N, Astrahantseff K, Szymansky A, Toedling J, Thole-Kliesch TM, Ballagee A, Lodrini M, Künkele A, Truss M, Heukamp LC, Mathia S, Hertwig F, Rosenberger C, Eggert A, Deubzer HE, Schulte JH — Journal of clinical medicine. 2024 (PMID: 39458030)
- [Intracranial response to capmatinib after progression on crizotinib in a patient with MET exon 14 skipping non-small cell lung cancer-a case report.](https://pubmed.ncbi.nlm.nih.gov/39118880/) — Jóri B, Bundschuh O, Falk M, Heukamp LC, Kluge A, Tiemann M, Willborn KC, Woitzik J, Griesinger F — Translational lung cancer research. 2024 (PMID: 39118880)
- [Evaluation of the Prognostic Impact of SP263-Evaluated PD-L1 Expression in Patients with Stage III Non-Small Cell Lung Cancer (NSLC) Treated with Radio-Chemotherapy.](https://pubmed.ncbi.nlm.nih.gov/38540301/) — Wagner JN, Roeper J, Heukamp L, Falk M, Willborn K, Griesinger F — Biomedicines. 2024 (PMID: 38540301)
- [High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency-Associated Genomic Instability in Ovarian Cancer.](https://pubmed.ncbi.nlm.nih.gov/38513168/) — Pfarr N, von Schwarzenberg K, Zocholl D, Merkelbach-Bruse S, Siemanowski J, Mayr EM, Herold S, Kleo K, Heukamp LC, Willing EM, Menzel M, Lehmann U, Bartels S, Chakraborty S, Baretton G, Demes MC, Döring C, Kazdal D, Budczies J, Rad R, Wild P, Christinat Y, McKee T, Schirmacher P, Horst D, Büttner R, Stenzinger A, Sehouli J, Vollbrecht C, Hummel M, Braicu EI, Weichert W, German HRD assay Harmonization Consortium — JCO precision oncology. 2024 (PMID: 38513168)
- [Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns.](https://pubmed.ncbi.nlm.nih.gov/38201288/) — Lohanadan K, Assent M, Linnemann A, Schuld J, Heukamp LC, Krause K, Vorgerd M, Reimann J, Schänzer A, Kirfel G, Fürst DO, Van der Ven PFM — Cells. 2023 (PMID: 38201288)
- [The Combined Therapy of Cabozantinib, Crizotinib, and Osimertinib in a Lung Cancer Patient with Acquired MET Amplification and Resistance Mutations.](https://pubmed.ncbi.nlm.nih.gov/37887535/) — Jóri B, Vössing C, Pirngruber J, Willing EM, Arndt K, Falk M, Tiemann M, Heukamp LC, Hoffknecht P — Current oncology (Toronto, Ont.). 2023 (PMID: 37887535)
- [Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation.](https://pubmed.ncbi.nlm.nih.gov/37444554/) — Willing EM, Vollbrecht C, Vössing C, Weist P, Schallenberg S, Herbst JM, Schatz S, Jóri B, Bataillon G, Harter P, Salutari V, Martin AG, Vergote I, Colombo N, Roeper J, Berg T, Berger R, Kah B, Noettrup TJ, Falk M, Arndt K, Polten A, Ray-Coquard I, Selzam F, Pirngruber J, Schmidt S, Hummel M, Tiemann M, Horst D, Sehouli J, Pujade-Lauraine E, Tiemann K, Braicu EI, Heukamp LC — Cancers. 2023 (PMID: 37444554)
- [Response to (K)RAS(G12C) and EGFR Inhibition in a Patient With NRAS(G12C)-Mutated Rectal Cancer.](https://pubmed.ncbi.nlm.nih.gov/37262393/) — Möhrmann L, Cuberi A, Brückmann S, Stasik S, Heukamp LC, Bornhäuser M, Glimm H, Folprecht G — JCO precision oncology. 2023 (PMID: 37262393)
- [Acquired G2032R Resistance Mutation in ROS1 to Lorlatinib Therapy Detected with Liquid Biopsy.](https://pubmed.ncbi.nlm.nih.gov/36135089/) — Jóri B, Falk M, Hövel I, Weist P, Tiemann M, Heukamp LC, Griesinger F — Current oncology (Toronto, Ont.). 2022 (PMID: 36135089)
- [The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability.](https://pubmed.ncbi.nlm.nih.gov/36078047/) — Geers B, Hagenstein J, Endig J, Ulrich H, Fleig L, Sprezyna P, Mikulec J, Heukamp L, Tiegs G, Diehl L — Cells. 2022 (PMID: 36078047)
- [Cell-free tumor DNA, CA125 and HE4 for the objective assessment of tumor burden in patients with advanced high-grade serous ovarian cancer.](https://pubmed.ncbi.nlm.nih.gov/35130283/) — Heitz F, Lakis S, Harter P, Heikaus S, Sehouli J, Talwar J, Menon R, Ataseven B, Bertrand M, Schneider S, Mariotti E, Bommert M, Müller JN, Prader S, Leenders F, Hengsbach A, Gloeckner C, Braicu EI, Heukamp LC, du Bois A, Heuckmann JM — PloS one. 2022 (PMID: 35130283)
- [TP53 co-mutations as an independent prognostic factor in 2nd and further line therapy-EGFR mutated non-small cell lung cancer IV patients treated with osimertinib.](https://pubmed.ncbi.nlm.nih.gov/35242623/) — Roeper J, Christopoulos P, Falk M, Heukamp LC, Tiemann M, Stenzinger A, Thomas M, Griesinger F — Translational lung cancer research. 2022 (PMID: 35242623)
- [Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl(4) Exposure in Mice.](https://pubmed.ncbi.nlm.nih.gov/34769006/) — Unrau L, Endig J, Goltz D, Sprezyna P, Ulrich H, Hagenstein J, Geers B, Kaftan K, Heukamp LC, Tiegs G, Diehl L — International journal of molecular sciences. 2021 (PMID: 34769006)
- [Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors.](https://pubmed.ncbi.nlm.nih.gov/34673351/) — Ramdani HO, Falk M, Heukamp LC, Schatz S, Tiemann M, Wesseler C, Diehl L, Schuuring E, Groen HJM, Griesinger F — Pathology, research and practice. 2021 (PMID: 34673351)
- [Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing.](https://pubmed.ncbi.nlm.nih.gov/34442335/) — Szymansky A, Kruetzfeldt LM, Heukamp LC, Hertwig F, Theissen J, Deubzer HE, Willing EM, Menon R, Fuchs S, Thole T, Schulte S, Schmelz K, Künkele A, Lang P, Fuchs J, Eggert A, Eckert C, Fischer M, Henssen AG, Rodriguez-Fos E, Schulte JH — Journal of personalized medicine. 2021 (PMID: 34442335)
- [Comparison of Resistance Spectra after First and Second Line Osimertinib Treatment Detected by Liquid Biopsy.](https://pubmed.ncbi.nlm.nih.gov/34201252/) — Jóri B, Schatz S, Kaller L, Kah B, Roeper J, Ramdani HO, Diehl L, Hoffknecht P, Grohé C, Griesinger F, Tiemann M, Heukamp LC, Falk M — Cancers. 2021 (PMID: 34201252)
- [Corrigendum to "Biomarker testing in non-small cell lung cancer in routine care: Analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315)" [Lung Cancer 152 (2021) 174-184].](https://pubmed.ncbi.nlm.nih.gov/34049721/) — Griesinger F, Eberhardt W, Nusch A, Reiser M, Zahn MO, Maintz C, Bernhardt C, Losem C, Stenzinger A, Heukamp LC, Büttner R, Marschner N, Jänicke M, Fleitz A, Spring L, Sahlmann J, Karatas A, Hipper A, Weichert W, Heilmann M, Sadjadian P, Gleiber W, Grah C, Waller CF, Reck M, Rittmeyer A, Christopoulos P, Sebastian M, Thomas M, CRISP Registry Group — Lung cancer (Amsterdam, Netherlands). 2021 (PMID: 34049721)
- [BRAF mutations and BRAF mutation functional class have no negative impact on the clinical outcome of advanced NSCLC and associate with susceptibility to immunotherapy.](https://pubmed.ncbi.nlm.nih.gov/33872981/) — Wiesweg M, Preuß C, Roeper J, Metzenmacher M, Eberhardt W, Stropiep U, Wedeken K, Reis H, Herold T, Darwiche K, Aigner C, Stuschke M, Schildhaus HU, Schmid KW, Falk M, Heukamp L, Tiemann M, Griesinger F, Schuler M — European journal of cancer (Oxford, England : 1990). 2021 (PMID: 33872981)
- [Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras (LSL-G12V) Driven Lung Cancer Mouse Model.](https://pubmed.ncbi.nlm.nih.gov/34257546/) — Meder L, Florin A, Ozretić L, Nill M, Koker M, Meemboor S, Radtke F, Diehl L, Ullrich RT, Odenthal M, Büttner R, Heukamp LC — Pathology oncology research : POR. 2021 (PMID: 34257546)
- [NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection.](https://pubmed.ncbi.nlm.nih.gov/33868252/) — Tosetti B, Ward B, Grumme D, Herb M, Schramm M, Utermöhlen O, Heukamp LC, Krönke M, Krut O — Frontiers in immunology. 2021 (PMID: 33868252)
- [Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis.](https://pubmed.ncbi.nlm.nih.gov/33778057/) — Iyer A, Radonic T, Heukamp LC, Thunnissen E, Daniels JMA — ERJ open research. 2021 (PMID: 33778057)
- [KRAS G12C-mutated advanced non-small cell lung cancer: A real-world cohort from the German prospective, observational, nation-wide CRISP Registry (AIO-TRK-0315).](https://pubmed.ncbi.nlm.nih.gov/33611226/) — Sebastian M, Eberhardt WEE, Hoffknecht P, Metzenmacher M, Wehler T, Kokowski K, Alt J, Schütte W, Büttner R, Heukamp LC, Stenzinger A, Jänicke M, Fleitz A, Zacharias S, Dille S, Hipper A, Sandberg M, Weichert W, Groschek M, von der Heyde E, Rauh J, Dechow T, Thomas M, Griesinger F, CRISP Registry Group — Lung cancer (Amsterdam, Netherlands). 2021 (PMID: 33611226)
- [Lorlatinib in pretreated ALK- or ROS1-positive lung cancer and impact of TP53 co-mutations: results from the German early access program.](https://pubmed.ncbi.nlm.nih.gov/33613692/) — Frost N, Christopoulos P, Kauffmann-Guerrero D, Stratmann J, Riedel R, Schaefer M, Alt J, Gütz S, Christoph DC, Laack E, Faehling M, Fischer R, Fenchel K, Haen S, Heukamp L, Schulz C, Griesinger F — Therapeutic advances in medical oncology. 2021 (PMID: 33613692)
- [[Diagnosis and therapy of tumors with NTRK gene fusion].](https://pubmed.ncbi.nlm.nih.gov/33258061/) — Stenzinger A, van Tilburg CM, Tabatabai G, Länger F, Graf N, Griesinger F, Heukamp LC, Hummel M, Klingebiel T, Hettmer S, Vokuhl C, Merkelbach-Bruse S, Overkamp F, Reichardt P, Scheer M, Weichert W, Westphalen CB, Bokemeyer C, Ivanyi P, Loges S, Schirmacher P, Wörmann B, Bielack S, Seufferlein TTW — Der Pathologe. 2021 (PMID: 33258061)
- [ALK alterations in salivary gland carcinomas.](https://pubmed.ncbi.nlm.nih.gov/33237469/) — Majewska H, Gorczyński A, Czapiewski P, Menon R, Mueller J, Lakis S, Heuckmann JM, Laco J, Gupta R, Andreasen S, Stodulski D, Iliszko M, Dziadziuszko R, Jassem J, Heukamp LC, Biernat W — Virchows Archiv : an international journal of pathology. 2021 (PMID: 33237469)
- [Biomarker testing in non-small cell lung cancer in routine care: Analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP Registry (AIO-TRK-0315).](https://pubmed.ncbi.nlm.nih.gov/33358484/) — Griesinger F, Eberhardt W, Nusch A, Reiser M, Zahn MO, Maintz C, Bernhardt C, Losem C, Stenzinger A, Heukamp LC, Büttner R, Marschner N, Jänicke M, Fleitz A, Spring L, Sahlmann J, Karatas A, Hipper A, Weichert W, Heilmann M, Sadjadian P, Gleiber W, Grah C, Waller CF, Reck M, Rittmeyer A, Christopoulos P, Sebastian M, Thomas M, CRISP Registry Group — Lung cancer (Amsterdam, Netherlands). 2021 (PMID: 33358484)
- [Risk stratification of EGFR(+) lung cancer diagnosed with panel-based next-generation sequencing.](https://pubmed.ncbi.nlm.nih.gov/32871455/) — Christopoulos P, Kirchner M, Roeper J, Saalfeld F, Janning M, Bozorgmehr F, Magios N, Kazdal D, Volckmar AL, Brückner LM, Bochtler T, Kriegsmann M, Endris V, Penzel R, Kriegsmann K, Eichhorn M, Herth FJF, Heussel CP, El Shafie RA, Schneider MA, Muley T, Meister M, Faehling M, Fischer JR, Heukamp L, Schirmacher P, Bischoff H, Wermke M, Loges S, Griesinger F, Stenzinger A, Thomas M — Lung cancer (Amsterdam, Netherlands). 2020 (PMID: 32871455)
- [Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer.](https://pubmed.ncbi.nlm.nih.gov/32599951/) — Schatz S, Falk M, Jóri B, Ramdani HO, Schmidt S, Willing EM, Menon R, Groen HJM, Diehl L, Kröger M, Wesseler C, Griesinger F, Hoffknecht P, Tiemann M, Heukamp LC — Cancers. 2020 (PMID: 32599951)
- [Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors.](https://pubmed.ncbi.nlm.nih.gov/32397977/) — Wagener-Ryczek S, Heydt C, Süptitz J, Michels S, Falk M, Alidousty C, Fassunke J, Ihle MA, Tiemann M, Heukamp L, Wolf J, Büttner R, Merkelbach-Bruse S — BMC cancer. 2020 (PMID: 32397977)
- [Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC.](https://pubmed.ncbi.nlm.nih.gov/32348765/) — Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, Dietlein F, Borchmann S, Chatterjee S, Siobal M, Schöttle J, Florin A, Koker M, Nill M, Ozretić L, Uhlenbrock N, Smith S, Büttner R, Miao H, Wang B, Reinhardt HC, Rauh D, Hallek M, Acker-Palmer A, Heukamp LC, Ullrich RT — Cell reports. 2020 (PMID: 32348765)
- [Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis.](https://pubmed.ncbi.nlm.nih.gov/32260486/) — Schulte R, Wohlleber D, Unrau L, Geers B, Metzger C, Erhardt A, Tiegs G, van Rooijen N, Heukamp LC, Klotz L, Knolle PA, Diehl L — International journal of molecular sciences. 2020 (PMID: 32260486)
- [Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary.](https://pubmed.ncbi.nlm.nih.gov/31970771/) — Bochtler T, Reiling A, Endris V, Hielscher T, Volckmar AL, Neumann O, Kirchner M, Budczies J, Heukamp LC, Leichsenring J, Allgäuer M, Kazdal D, Löffler H, Weichert W, Schirmacher P, Stenzinger A, Krämer A — International journal of cancer. 2020 (PMID: 31970771)
- [TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC.](https://pubmed.ncbi.nlm.nih.gov/32076486/) — Roeper J, Falk M, Chalaris-Rißmann A, Lueers AC, Ramdani H, Wedeken K, Stropiep U, Diehl L, Tiemann M, Heukamp LC, Otto-Sobotka F, Griesinger F — Oncotarget. 2020 (PMID: 32076486)
- [Acute Liver Injury after CCl(4) Administration is Independent of Smad7 Expression in Myeloid Cells.](https://pubmed.ncbi.nlm.nih.gov/31698731/) — Endig J, Unrau L, Sprezyna P, Rading S, Karsak M, Goltz D, Heukamp LC, Tiegs G, Diehl L — International journal of molecular sciences. 2019 (PMID: 31698731)
- [ALK immunohistochemistry positive, FISH negative NSCLC is infrequent, but associated with impaired survival following treatment with crizotinib.](https://pubmed.ncbi.nlm.nih.gov/31630043/) — Thunnissen E, Lissenberg-Witte BI, van den Heuvel MM, Monkhorst K, Skov BG, Sørensen JB, Mellemgaard A, Dingemans AMC, Speel EJM, de Langen AJ, Hashemi SMS, Bahce I, van der Drift MA, Looijen-Salamon MG, Gosney J, Postmus PE, Samii SMS, Duplaquet F, Weynand B, Durando X, Penault-Llorca F, Finn S, Grady AO, Oz B, Akyurek N, Buettner R, Wolf J, Bubendorf L, Duin S, Marondel I, Heukamp LC, Timens W, Schuuring EMD, Pauwels P, Smit EF — Lung cancer (Amsterdam, Netherlands). 2019 (PMID: 31630043)
- [Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial.](https://pubmed.ncbi.nlm.nih.gov/30978502/) — Michels S, Massutí B, Schildhaus HU, Franklin J, Sebastian M, Felip E, Grohé C, Rodriguez-Abreu D, Abdulla DSY, Bischoff H, Brandts C, Carcereny E, Corral J, Dingemans AC, Pereira E, Fassunke J, Fischer RN, Gardizi M, Heukamp L, Insa A, Kron A, Menon R, Persigehl T, Reck M, Riedel R, Rothschild SI, Scheel AH, Scheffler M, Schmalz P, Smit EF, Limburg M, Provencio M, Karachaliou N, Merkelbach-Bruse S, Hellmich M, Nogova L, Büttner R, Rosell R, Wolf J — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 (PMID: 30978502)
- [Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Lung Cancer.](https://pubmed.ncbi.nlm.nih.gov/32914023/) — Michels S, Heydt C, van Veggel B, Deschler-Baier B, Pardo N, Monkhorst K, Rüsseler V, Stratmann J, Griesinger F, Steinhauser S, Kostenko A, Diebold J, Fassunke J, Fischer R, Engel-Riedel W, Gautschi O, Geissinger E, Haneder S, Ihle MA, Kopp HG, de Langen AJ, Martinez-Marti A, Nogova L, Persigehl T, Plenker D, Puesken M, Rodermann E, Rosenwald A, Scheel AH, Scheffler M, Spengler W, Seggewiss-Bernhardt R, Brägelmann J, Sebastian M, Vrugt B, Hellmich M, Sos ML, Heukamp LC, Felip E, Merkelbach-Bruse S, Smit EF, Büttner R, Wolf J — JCO precision oncology. 2019 (PMID: 32914023)
- [The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines.](https://pubmed.ncbi.nlm.nih.gov/30885150/) — Klenke S, Akdeli N, Stelmach P, Heukamp L, Schulte JH, Bachmann HS — BMC cancer. 2019 (PMID: 30885150)
- [The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production.](https://pubmed.ncbi.nlm.nih.gov/30382149/) — Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp LC, Knolle PA, Kolanus W, Diehl L — Scientific reports. 2018 (PMID: 30382149)
- [Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non-Small Cell Lung Carcinoma (NSCLC).](https://pubmed.ncbi.nlm.nih.gov/29615460/) — Frank R, Scheffler M, Merkelbach-Bruse S, Ihle MA, Kron A, Rauer M, Ueckeroth F, König K, Michels S, Fischer R, Eisert A, Fassunke J, Heydt C, Serke M, Ko YD, Gerigk U, Geist T, Kaminsky B, Heukamp LC, Clement-Ziza M, Büttner R, Wolf J — Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 (PMID: 29615460)
- [Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica.](https://pubmed.ncbi.nlm.nih.gov/29714649/) — Mahjoubi L, Cecchi F, Massard C, Calabro F, Gazzah A, Bahleda R, Jamme P, Gelli M, Goere D, Lacroix L, Adam J, Heukamp L, Trenta P, Hembrough T, Soria JC, Sternberg C, Ducreux M — Tumori. 2018 (PMID: 29714649)
- [LIN28B enhanced tumorigenesis in an autochthonous KRAS(G12V)-driven lung carcinoma mouse model.](https://pubmed.ncbi.nlm.nih.gov/29503447/) — Meder L, König K, Dietlein F, Macheleidt I, Florin A, Ercanoglu MS, Rommerscheidt-Fuss U, Koker M, Schön G, Odenthal M, Klein F, Büttner R, Schulte JH, Heukamp LC, Ullrich RT — Oncogene. 2018 (PMID: 29503447)
- [Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany.](https://pubmed.ncbi.nlm.nih.gov/28971346/) — Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I, Morris JC, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L, Beyer T — Molecular imaging and biology. 2018 (PMID: 28971346)
- [Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients.](https://pubmed.ncbi.nlm.nih.gov/29284707/) — Plenker D, Bertrand M, de Langen AJ, Riedel R, Lorenz C, Scheel AH, Müller J, Brägelmann J, Daßler-Plenker J, Kobe C, Persigehl T, Kluge A, Wurdinger T, Schellen P, Hartmann G, Zacherle T, Menon R, Thunnissen E, Büttner R, Griesinger F, Wolf J, Heukamp L, Sos ML, Heuckmann JM — Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 (PMID: 29284707)
- [Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer.](https://pubmed.ncbi.nlm.nih.gov/28851100/) — Scheel AH, Baenfer G, Baretton G, Dietel M, Diezko R, Henkel T, Heukamp LC, Jasani B, Jöhrens K, Kirchner T, Lasitschka F, Petersen I, Reu S, Schildhaus HU, Schirmacher P, Schwamborn K, Sommer U, Stoss O, Tiemann M, Warth A, Weichert W, Wolf J, Büttner R, Rüschoff J — Histopathology. 2018 (PMID: 28851100)
- [Detection of Discrepant Driver Mutations in a Patient with Two Synchronous Primary Non-Small Cell Lung Cancers (NSCLCs) with Liquid Biopsy.](https://pubmed.ncbi.nlm.nih.gov/29074212/) — Lakis S, Heukamp LC, Griesinger F — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2017 (PMID: 29074212)
- [Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.](https://pubmed.ncbi.nlm.nih.gov/28930680/) — Brägelmann J, Dammert MA, Dietlein F, Heuckmann JM, Choidas A, Böhm S, Richters A, Basu D, Tischler V, Lorenz C, Habenberger P, Fang Z, Ortiz-Cuaran S, Leenders F, Eickhoff J, Koch U, Getlik M, Termathe M, Sallouh M, Greff Z, Varga Z, Balke-Want H, French CA, Peifer M, Reinhardt HC, Örfi L, Kéri G, Ansén S, Heukamp LC, Büttner R, Rauh D, Klebl BM, Thomas RK, Sos ML — Cell reports. 2017 (PMID: 28930680)
- [Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens.](https://pubmed.ncbi.nlm.nih.gov/28751246/) — Müller JN, Falk M, Talwar J, Neemann N, Mariotti E, Bertrand M, Zacherle T, Lakis S, Menon R, Gloeckner C, Tiemann M, Heukamp LC, Thomas RK, Griesinger F, Heuckmann JM — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2017 (PMID: 28751246)
- [RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.](https://pubmed.ncbi.nlm.nih.gov/28427187/) — Gottlieb A, Althoff K, Grunewald L, Thor T, Odersky A, Schulte M, Deubzer HE, Heukamp L, Eggert A, Schramm A, Schulte JH, Künkele A — Oncotarget. 2017 (PMID: 28427187)
- [ALK(G1269A) mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor.](https://pubmed.ncbi.nlm.nih.gov/29872693/) — Michels SYF, Scheel AH, Wündisch T, Heuckmann JM, Menon R, Puesken M, Kobe C, Pasternack H, Heydt C, Scheffler M, Fischer R, Schultheis AM, Merkelbach-Bruse S, Heukamp L, Büttner R, Wolf J — NPJ precision oncology. 2017 (PMID: 29872693)
- [Correction: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.](https://pubmed.ncbi.nlm.nih.gov/28283535/) — Ladang A, Rapino F, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P, Chariot A — The Journal of experimental medicine. 2017 (PMID: 28283535)
- [The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.](https://pubmed.ncbi.nlm.nih.gov/28036269/) — Pajtler KW, Sadowski N, Ackermann S, Althoff K, Schönbeck K, Batzke K, Schäfers S, Odersky A, Heukamp L, Astrahantseff K, Künkele A, Deubzer HE, Schramm A, Sprüssel A, Thor T, Lindner S, Eggert A, Fischer M, Schulte JH — Oncotarget. 2017 (PMID: 28036269)
- [[Predictive PD-L1 immunohistochemistry for non-small cell lung cancer : Current state of the art and experiences of the first German harmonization study].](https://pubmed.ncbi.nlm.nih.gov/27510417/) — Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Büttner R — Der Pathologe. 2016 (PMID: 27510417)
- [Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.](https://pubmed.ncbi.nlm.nih.gov/27811057/) — Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P — The Journal of experimental medicine. 2016 (PMID: 27811057)
- [Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer.](https://pubmed.ncbi.nlm.nih.gov/27696251/) — Latteyer S, Tiedje V, König K, Ting S, Heukamp LC, Meder L, Schmid KW, Führer D, Moeller LC — Endocrine. 2016 (PMID: 27696251)
- [Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas.](https://pubmed.ncbi.nlm.nih.gov/27389313/) — Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Buettner R — Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2016 (PMID: 27389313)
- [Effectiveness of crizotinib in a patient with ALK IHC-positive/FISH-negative metastatic lung adenocarcinoma.](https://pubmed.ncbi.nlm.nih.gov/27393517/) — Rosoux A, Pauwels P, Duplaquet F, D'Haene N, Weynand B, Delos M, Menon R, Heukamp LC, Thunnissen E, Ocak S — Lung cancer (Amsterdam, Netherlands). 2016 (PMID: 27393517)
- [Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors.](https://pubmed.ncbi.nlm.nih.gov/27252416/) — Ortiz-Cuaran S, Scheffler M, Plenker D, Dahmen L, Scheel AH, Fernandez-Cuesta L, Meder L, Lovly CM, Persigehl T, Merkelbach-Bruse S, Bos M, Michels S, Fischer R, Albus K, König K, Schildhaus HU, Fassunke J, Ihle MA, Pasternack H, Heydt C, Becker C, Altmüller J, Ji H, Müller C, Florin A, Heuckmann JM, Nuernberg P, Ansén S, Heukamp LC, Berg J, Pao W, Peifer M, Buettner R, Wolf J, Thomas RK, Sos ML — Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 (PMID: 27252416)
- [Retraction Notice to: Cytohesins Are Cytoplasmic ErbB Receptor Activators.](https://pubmed.ncbi.nlm.nih.gov/27203114/) — Bill A, Schmitz A, Albertoni B, Song JN, Heukamp LC, Walrafen D, Thorwirth F, Verveer PJ, Zimmer S, Meffert L, Schreiber A, Chatterjee S, Thomas RK, Ullrich RT, Lang T, Famulok M — Cell. 2016 (PMID: 27203114)
- [A Novel EGFR(C797) Variant Detected in a Pleural Biopsy Specimen from an Osimertinib-Treated Patient Using a Comprehensive Hybrid Capture-Based Next-Generation Sequencing Assay.](https://pubmed.ncbi.nlm.nih.gov/27086175/) — Menon R, Müller J, Schneider P, Lakis S, Thress K, Wolf J, Heukamp L, Heuckmann JM, Griesinger F — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2016 (PMID: 27086175)
- [The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.](https://pubmed.ncbi.nlm.nih.gov/26980769/) — Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A — Cancer research. 2016 (PMID: 26980769)
- [Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients.](https://pubmed.ncbi.nlm.nih.gov/26762747/) — Michels S, Scheel AH, Scheffler M, Schultheis AM, Gautschi O, Aebersold F, Diebold J, Pall G, Rothschild S, Bubendorf L, Hartmann W, Heukamp L, Schildhaus HU, Fassunke J, Ihle MA, Künstlinger H, Heydt C, Fischer R, Nogovà L, Mattonet C, Hein R, Adams A, Gerigk U, Schulte W, Lüders H, Grohé C, Graeven U, Müller-Naendrup C, Draube A, Kambartel KO, Krüger S, Schulze-Olden S, Serke M, Engel-Riedel W, Kaminsky B, Randerath W, Merkelbach-Bruse S, Büttner R, Wolf J — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2016 (PMID: 26762747)
- [Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group.](https://pubmed.ncbi.nlm.nih.gov/26645239/) — Vollbrecht C, Werner R, Walter RF, Christoph DC, Heukamp LC, Peifer M, Hirsch B, Burbat L, Mairinger T, Schmid KW, Wohlschlaeger J, Mairinger FD — British journal of cancer. 2015 (PMID: 26645239)
- [Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.](https://pubmed.ncbi.nlm.nih.gov/26631615/) — Henssen A, Althoff K, Odersky A, Beckers A, Koche R, Speleman F, Schäfers S, Bell E, Nortmeyer M, Westermann F, De Preter K, Florin A, Heukamp L, Spruessel A, Astrahanseff K, Lindner S, Sadowski N, Schramm A, Astorgues-Xerri L, Riveiro ME, Eggert A, Cvitkovic E, Schulte JH — Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 (PMID: 26631615)
- [Successful AZD9291 Therapy Based on Circulating T790M.](https://pubmed.ncbi.nlm.nih.gov/26709490/) — Gautschi O, Aebi S, Heukamp LC — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2015 (PMID: 26709490)
- [Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer.](https://pubmed.ncbi.nlm.nih.gov/26540572/) — Schöttle J, Chatterjee S, Volz C, Siobal M, Florin A, Rokitta D, Hinze Y, Dietlein F, Plenker D, König K, Albus K, Heuckmann JM, Rauh D, Franz T, Neumaier B, Fuhr U, Heukamp LC, Ullrich RT — Oncotarget. 2015 (PMID: 26540572)
- [Membranous CD24 expression as detected by the monoclonal antibody SWA11 is a prognostic marker in non-small cell lung cancer patients.](https://pubmed.ncbi.nlm.nih.gov/26578846/) — Majores M, Schindler A, Fuchs A, Stein J, Heukamp L, Altevogt P, Kristiansen G — BMC clinical pathology. 2015 (PMID: 26578846)
- [Implementing amplicon-based next generation sequencing in the diagnosis of small cell lung carcinoma metastases.](https://pubmed.ncbi.nlm.nih.gov/26546837/) — Meder L, König K, Fassunke J, Ozretić L, Wolf J, Merkelbach-Bruse S, Heukamp LC, Buettner R — Experimental and molecular pathology. 2015 (PMID: 26546837)
- [Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.](https://pubmed.ncbi.nlm.nih.gov/26527802/) — Ladang A, Rapino F, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P, Chariot A — The Journal of experimental medicine. 2015 (PMID: 26527802)
- [Endogenous Il10 alleviates the systemic antiviral cellular immune response and T cell-mediated immunopathology in select organs of acutely LCMV-infected mice.](https://pubmed.ncbi.nlm.nih.gov/26506472/) — Jakobshagen K, Ward B, Baschuk N, Huss S, Brunn A, Malecki M, Fiolka M, Rappl G, Corogeanu D, Karow U, Schiller P, Abken H, Heukamp LC, Deckert M, Krönke M, Utermöhlen O — The American journal of pathology. 2015 (PMID: 26506472)
- [[Cytological material for molecular pathology].](https://pubmed.ncbi.nlm.nih.gov/26483251/) — Heukamp LC, Bubendorf L — Der Pathologe. 2015 (PMID: 26483251)
- [Mutation Profiling of Lung Cancers with Long-Term Response to Gefitinib Therapy.](https://pubmed.ncbi.nlm.nih.gov/26599269/) — Gautschi O, Stadelmann C, Aebersold-Keller F, König K, Büttner R, Heukamp LC, Betticher D, Baumann C, Buser K, Calderoni A, Casty A, DʼAddario G, Irlé C, Mamot C, Morant R, Trojan A, Pellicioli E, Jehle-Schwertfeger S, Aebi S, Diebold J — Oncology research and treatment. 2015 (PMID: 26599269)
- [NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas.](https://pubmed.ncbi.nlm.nih.gov/26340530/) — Meder L, König K, Ozretić L, Schultheis AM, Ueckeroth F, Ade CP, Albus K, Boehm D, Rommerscheidt-Fuss U, Florin A, Buhl T, Hartmann W, Wolf J, Merkelbach-Bruse S, Eilers M, Perner S, Heukamp LC, Buettner R — International journal of cancer. 2016 (PMID: 26340530)
- [Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.](https://pubmed.ncbi.nlm.nih.gov/26053092/) — Grünewald I, Vollbrecht C, Meinrath J, Meyer MF, Heukamp LC, Drebber U, Quaas A, Beutner D, Hüttenbrink KB, Wardelmann E, Hartmann W, Büttner R, Odenthal M, Stenner M — Oncotarget. 2015 (PMID: 26053092)
- [Comprehensive genomic profiles of small cell lung cancer.](https://pubmed.ncbi.nlm.nih.gov/26168399/) — George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK — Nature. 2015 (PMID: 26168399)
- [Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients.](https://pubmed.ncbi.nlm.nih.gov/26102443/) — König K, Peifer M, Fassunke J, Ihle MA, Künstlinger H, Heydt C, Stamm K, Ueckeroth F, Vollbrecht C, Bos M, Gardizi M, Scheffler M, Nogova L, Leenders F, Albus K, Meder L, Becker K, Florin A, Rommerscheidt-Fuss U, Altmüller J, Kloth M, Nürnberg P, Henkel T, Bikár SE, Sos ML, Geese WJ, Strauss L, Ko YD, Gerigk U, Odenthal M, Zander T, Wolf J, Merkelbach-Bruse S, Buettner R, Heukamp LC — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2015 (PMID: 26102443)
- [Mutational dynamics between primary and relapse neuroblastomas.](https://pubmed.ncbi.nlm.nih.gov/26121086/) — Schramm A, Köster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, Stephan H, Schröder C, Heukamp L, Engesser A, Kahlert Y, Theissen J, Hero B, Roels F, Altmüller J, Nürnberg P, Astrahantseff K, Gloeckner C, De Preter K, Plass C, Lee S, Lode HN, Henrich KO, Gartlgruber M, Speleman F, Schmezer P, Westermann F, Rahmann S, Fischer M, Eggert A, Schulte JH — Nature genetics. 2015 (PMID: 26121086)
- [Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing.](https://pubmed.ncbi.nlm.nih.gov/26053404/) — Vollbrecht C, Mairinger FD, Koitzsch U, Peifer M, Koenig K, Heukamp LC, Crispatzu G, Wilden L, Kreuzer KA, Hallek M, Odenthal M, Herling CD, Buettner R — PloS one. 2015 (PMID: 26053404)
- [Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient.](https://pubmed.ncbi.nlm.nih.gov/26001148/) — Scheffler M, Merkelbach-Bruse S, Bos M, Fassunke J, Gardizi M, Michels S, Groneck L, Schultheis AM, Malchers F, Leenders F, Kobe C, König K, Heukamp LC, Sos ML, Thomas RK, Büttner R, Wolf J — Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2015 (PMID: 26001148)
- [ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability.](https://pubmed.ncbi.nlm.nih.gov/25868855/) — Scheffler M, Schultheis A, Teixido C, Michels S, Morales-Espinosa D, Viteri S, Hartmann W, Merkelbach-Bruse S, Fischer R, Schildhaus HU, Fassunke J, Sebastian M, Serke M, Kaminsky B, Randerath W, Gerigk U, Ko YD, Krüger S, Schnell R, Rothe A, Kropf-Sanchen C, Heukamp L, Rosell R, Büttner R, Wolf J — Oncotarget. 2015 (PMID: 25868855)
- [Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer.](https://pubmed.ncbi.nlm.nih.gov/26001389/) — Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt-Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R — Gut. 2016 (PMID: 26001389)
- [PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.](https://pubmed.ncbi.nlm.nih.gov/25473901/) — Scheffler M, Bos M, Gardizi M, König K, Michels S, Fassunke J, Heydt C, Künstlinger H, Ihle M, Ueckeroth F, Albus K, Serke M, Gerigk U, Schulte W, Töpelt K, Nogova L, Zander T, Engel-Riedel W, Stoelben E, Ko YD, Randerath W, Kaminsky B, Panse J, Becker C, Hellmich M, Merkelbach-Bruse S, Heukamp LC, Büttner R, Wolf J — Oncotarget. 2015 (PMID: 25473901)
- [MiR-34a deficiency accelerates medulloblastoma formation in vivo.](https://pubmed.ncbi.nlm.nih.gov/25348795/) — Thor T, Künkele A, Pajtler KW, Wefers AK, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Sadowski N, Becker L, Garrett L, Hölter SM, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Schüller U, de Angelis MH, Eggert A, Schramm A, Schulte JH — International journal of cancer. 2015 (PMID: 25348795)
- [Targeting Tumor-Infiltrating B Cells in Cutaneous T-Cell Lymphoma.](https://pubmed.ncbi.nlm.nih.gov/25348001/) — Theurich S, Schlaak M, Steguweit H, Heukamp LC, Wennhold K, Kurschat P, Rabenhorst A, Hartmann K, Schlösser H, Shimabukuro-Vornhagen A, Holtick U, Hallek M, Stadler R, von Bergwelt-Baildon M — Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 (PMID: 25348001)
- [A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.](https://pubmed.ncbi.nlm.nih.gov/25174395/) — Althoff K, Beckers A, Bell E, Nortmeyer M, Thor T, Sprüssel A, Lindner S, De Preter K, Florin A, Heukamp LC, Klein-Hitpass L, Astrahantseff K, Kumps C, Speleman F, Eggert A, Westermann F, Schramm A, Schulte JH — Oncogene. 2015 (PMID: 25174395)
- [Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.](https://pubmed.ncbi.nlm.nih.gov/25173427/) — Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R, Ansén S, Perner S, Brockmann M, Bos M, Wolf J, Gardizi M, Wright GM, Solomon B, Russell PA, Rogers TM, Suehara Y, Red-Brewer M, Tieu R, de Stanchina E, Wang Q, Zhao Z, Johnson DH, Horn L, Wong KK, Thomas RK, Ladanyi M, Pao W — Nature medicine. 2014 (PMID: 25173427)
- [Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnostics.](https://pubmed.ncbi.nlm.nih.gov/25105902/) — Heydt C, Fassunke J, Künstlinger H, Ihle MA, König K, Heukamp LC, Schildhaus HU, Odenthal M, Büttner R, Merkelbach-Bruse S — PloS one. 2014 (PMID: 25105902)
- [The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells.](https://pubmed.ncbi.nlm.nih.gov/24736599/) — Kurakula K, Vos M, Otermin Rubio I, Marinković G, Buettner R, Heukamp LC, Stap J, de Waard V, van Tiel CM, de Vries CJ — PloS one. 2014 (PMID: 24736599)
- [Transient antiangiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer.](https://pubmed.ncbi.nlm.nih.gov/24675359/) — Chatterjee S, Wieczorek C, Schöttle J, Siobal M, Hinze Y, Franz T, Florin A, Adamczak J, Heukamp LC, Neumaier B, Ullrich RT — Cancer research. 2014 (PMID: 24675359)
- [Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.](https://pubmed.ncbi.nlm.nih.gov/24670920/) — Fernandez-Cuesta L, Peifer M, Lu X, Sun R, Ozretić L, Seidal D, Zander T, Leenders F, George J, Müller C, Dahmen I, Pinther B, Bosco G, Konrad K, Altmüller J, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soltermann A, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M, Ansén S, Stoelben E, Wright GM, Russell P, Wainer Z, Solomon B, Field JK, Hyde R, Davies MP, Heukamp LC, Petersen I, Perner S, Lovly C, Cappuzzo F, Travis WD, Wolf J, Vingron M, Brambilla E, Haas SA, Buettner R, Thomas RK — Nature communications. 2014 (PMID: 24670920)
- [Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma.](https://pubmed.ncbi.nlm.nih.gov/24913676/) — Schütte U, Bisht S, Heukamp LC, Kebschull M, Florin A, Haarmann J, Hoffmann P, Bendas G, Buettner R, Brossart P, Feldmann G — Translational oncology. 2014 (PMID: 24913676)
- [Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer.](https://pubmed.ncbi.nlm.nih.gov/24593867/) — Fuchs A, König K, Heukamp LC, Fassunke J, Kirfel J, Huss S, Becker AJ, Büttner R, Majores M — Diagnostic pathology. 2014 (PMID: 24593867)
- [A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.](https://pubmed.ncbi.nlm.nih.gov/24556366/) — Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers J, Edelmann W, Heukamp LC, Reinhardt HC — Cancer discovery. 2014 (PMID: 24556366)
- [CD74-NRG1 fusions in lung adenocarcinoma.](https://pubmed.ncbi.nlm.nih.gov/24469108/) — Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Daßler J, Malchers F, Schöttle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmüller J, Becker C, Nürnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sänger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Buettner R, Zander T, Wolf J, Perner S, Ansén S, Haas SA, Yatabe Y, Thomas RK — Cancer discovery. 2014 (PMID: 24469108)
- [The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma.](https://pubmed.ncbi.nlm.nih.gov/24242212/) — Rothe A, Jachimowicz RD, Borchmann S, Madlener M, Keßler J, Reiners KS, Sauer M, Hansen HP, Ullrich RT, Chatterjee S, Borchmann P, Yazaki P, Koslowsky TC, Engert A, Heukamp LC, Hallek M, von Strandmann EP — International journal of cancer. 2014 (PMID: 24242212)

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